1348 Involvement of mast cells and CB1 in the pathogenesis of IgA vasculitis

IgA vasculitis is a disease causing the antibody immunoglobulin A to collect in small blood vessels, which become inflamed and leak affecting people of all age groups. The mechanisms remain unclear; however, studies suggest involvement mast cells progress vasculitis. To best our knowledge, limited human have been reported literature with detailed analysis cell character number purpose study determine role vasculitis, special emphasis on development pathogenesis By toluidine blue staining, chymase, tryptase, stem factor (SCF), cannabinoid receptor type 1 (CB1), c-kit immunohistochemical we examined specifically perivascular dermis patients Perivascular clearly increased compared healthy subjects. blue-positive cells, chymase stain-positive tryptase increase around vessels were statistically significant subjects, had same tendency. CB1 expression (p=0.003) epithelial was significantly upregulated Our results showed that might be involved inflammation Mast proinflammatory immunoregulatory effects, their possible functions are largely obscure. regulation may lead new therapeutic agents for